In this article, Lasker Award-winner Dr. H. Michael Shepard describes leading the team that identified the deadly HER2 gene’s role in the development of breast cancer; and the invention of, “Herceptin” to block HER2 (treating over 3 Million people to date).
Lasker Award-winner Sir Marc Feldmann describes how linking upregulated antigen presentation to autoimmunity led to an investigation of the role of cytokines in rheumatoid arthritis (RA), in collaboration with Ravinder Maini. And how those experiments defined the concept of a TNF-dependent cytokine cascade driving the manifestations of RA, which led to successful clinical trials of anti-TNF monoclonal antibody in RA patients, heralding a major change in medical practice.
In this article, Lasker Award-winner Dr. H. Michael Shepard describes leading the team that identified the deadly HER2 gene’s role in the development of breast cancer; and the invention of, “Herceptin” to block HER2 (treating over 3 Million people to date).
Patents to date by Sir Marc Feldmann and associates
A partial collection of articles by Dr. Shepard, along with supplementary notes
An inflammatory cytokine signature predicts COVID-19 severity and survival
Methods, diagnostics and therapies patented by Dr. Shepard and associates
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